A cikin maza da mata, hormone luteinizing ko LH yana taka muhimmiyar rawa wajen haihuwa. Lallai yana daga cikin kwayoyin halittar da aka sani da gonadotropins, masu gudanar da glandar haihuwa. Don haka cuta a cikin ɓoye ta na iya zama cikas ga yin ciki.

Luteinizing hormone ko LH (luteizing hormone) yana ɓoye ta hanyar pituitary na gaba. Yana da wani ɓangare na gonadotropins: yana sarrafawa, tare da sauran kwayoyin halitta, glandon jima'i (gonads), a cikin wannan yanayin ovaries a cikin mata da kuma gwajin jini a cikin maza.

A cikin mata

Tare da follicle stimulating hormone (FSH), LH yana taka muhimmiyar rawa a cikin sake zagayowar ovarian. Daidai hawan LH ne zai haifar da ovulation yayin jerin halayen sarkar:

• hypothalamus yana ɓoye gnRH (samar da gonadotropin hormone) wanda ke motsa pituitary gland shine yake;
• a cikin mayar da martani, pituitary gland shine yake ɓoye FSH a lokacin farkon lokaci na sake zagayowar (daga ranar farko ta haila zuwa ovulation);
• a ƙarƙashin tasirin FSH, wasu ƙwayoyin ovarian za su fara girma. Kwayoyin ovarian da ke kusa da balagaggen follicle na ovarian za su ƙara ɓoye isrogen;
• wannan karuwa a cikin matakin estrogen a cikin jini yana aiki akan hadaddun hypothalamic-pituitary kuma yana haifar da sakin LH mai yawa;
• a ƙarƙashin tasirin wannan haɓakar LH, tashin hankali a cikin follicle yana ƙaruwa. A ƙarshe yana karya kuma yana fitar da oocyte cikin bututu: wannan shine ovulation, wanda ke faruwa awanni 24 zuwa 36 bayan hawan LH.

Bayan ovulation, LH yana ci gaba da taka muhimmiyar rawa. Karkashin tasirinsa, tsagewar ovarian follicle ya canza zuwa wani gland da ake kira corpus luteum wanda hakan ke fitar da estrogen da progesterone, hormones biyu masu mahimmanci a farkon daukar ciki.

A cikin mutane

Kamar ovaries, gwaje-gwajen suna ƙarƙashin ikon FSH da LH. Ƙarshen yana ƙarfafa ƙwayoyin Leydig waɗanda ke da alhakin ɓoyewar testosterone. Sigar LH tana dawwama sosai bayan balaga.

Ana iya ba da shawarar adadin LH a yanayi daban-daban:

A cikin mata

• a gaban alamun precocious ko marigayi balaga;
• a yanayin rashin jinin haila;
• idan akwai wahala a cikin ciki: ana gudanar da kima na hormonal bisa tsari a matsayin wani ɓangare na ƙididdigar rashin haihuwa. Ya ƙunshi musamman ƙaddarar LH;
• gano yawan hawan LH a cikin fitsari shima yana sa a iya gane ranar haihuwa, sabili da haka a tantance tagar haihuwarsa domin a samu damar daukar ciki. Wannan shine ka'idar gwajin ovulation da ake siyarwa a cikin kantin magani;
• a gefe guda, ƙididdigar LH ba ta da sha'awa ga ganewar asali na menopause (HAS 2005) (1).

A cikin mutane

• a gaban alamun precocious ko marigayi balaga;
• idan akwai wahala a cikin ciki: Hakanan ana yin kima na hormonal a cikin maza. Ya haɗa da musamman gwajin LH.

An gwada LH daga gwajin jini mai sauƙi. A cikin mata, ana yin shi a ranar 2nd, 3rd ko 4th na sake zagayowar a cikin dakin gwaje-gwaje na tunani, a daidai lokacin da FSH da estradiol assays. A cikin yanayin amenorrhea (rashin lokaci), ana iya ɗaukar samfurin a kowane lokaci.

A cikin mahallin gano cutar marigayi ko balaga a cikin yarinya ko saurayi, za a fi son adadin fitsari. Gonadotropins FSH da LH ana ɓoye su a cikin yanayin bugun jini yayin lokacin balaga kuma ana kawar da su gaba ɗaya a cikin fitsari. Sakamakon fitsari don haka yana ba da damar mafi kyawun tantance matakan ɓoyayyen fiye da adadin maganin magani akan lokaci.

A cikin yara

Babban matakan FSH da LH na iya zama alamar balaga.

A cikin mata

A tsari, Babban matakin LH yana haifar da rashi na ovarian na farko (matsala tare da ovaries kansu suna haifar da ƙarancin gonadal) wanda zai iya zama saboda:

• wani anomaly na haihuwa na ovaries;
• rashin daidaituwa na chromosomal (musamman ciwon Turner);
• jiyya ko tiyata wanda ya shafi aikin ovarian (chemotherapy, radiotherapy);
• polycystic ovary syndrome (PCOS):
• thyroid cuta ko adrenal cuta;
• ciwon ovarian.

Sabanin haka, ƙananan matakin LH yana haifar da rashin lafiyar ovarian na biyu na babban asali (hypothalamus da pituitary) wanda ke haifar da rashi a cikin haɓakar gonadal. Ɗaya daga cikin abubuwan da suka fi dacewa shine prolactin pituitary adenoma.

A cikin mutane

Wani babban matakin LH wanda bai sabawa al'ada ba yana jagorantar ganewar asali zuwa gazawar gwaji na farko wanda zai iya zama saboda:

• rashin daidaituwa na chromosomal;
• rashin ci gaba na kwayoyin halitta (testicular agenesis);
• rauni na testicular;
• kamuwa da cuta;
• magani (radiotherapy, chemotherapy);
• ciwon ƙwayar cuta;
• cutar autoimmune.

Ƙananan matakin LH yana komawa zuwa rashin lafiya na babban asali, a cikin pituitary da hypothalamus (pituitary tumor misali) wanda ke haifar da gazawar gwaji na biyu.