Sakamakon ganewar asali na acromegaly yana da sauƙi (amma kawai lokacin da kake tunani game da shi), tun da yake ya haɗa da yin gwajin jini don sanin matakin GH da IGF-1. A cikin acromegaly, akwai babban matakin IGF-1 da GH, da sanin cewa ɓoyewar GH yawanci ba ta wuce lokaci ba, amma cewa a cikin acromegaly koyaushe yana da girma saboda ba a sake tsara shi ba. Tabbatacciyar ganewar dakin gwaje-gwaje ta dogara ne akan gwajin glucose. Tunda glucose yawanci yana rage siginar GH, gudanarwa ta baki na glucose yana ba da damar gano, ta hanyar gwaje-gwajen jini na gaba, cewa, a cikin acromegaly, ɓoyewar hormone girma ya kasance mai girma.

Da zarar an tabbatar da hypersecretion na GH, to ya zama dole a nemo asalinsa. A yau, ma'auni na zinariya shine MRI na kwakwalwa wanda zai iya nuna ƙwayar ƙwayar ƙwayar cuta. A cikin lokuta da ba kasafai ba, ciwace-ciwacen daji ce da ke wasu wurare (mafi yawanci a cikin kwakwalwa, huhu ko pancreas) wanda ke ɓoye wani hormone da ke aiki akan glandan pituitary, GHRH, wanda ke haɓaka samar da GH. Daga nan kuma za a gudanar da bincike mai zurfi don gano asalin wannan mugunyar sirrin.