Macrophage myofasciitis yana da alamun cututtuka na histopathological (cututtukan da ke shafar kyallen takarda). Waɗannan su ne sakamakon myopathological, wato tasirin tsokar tsoka.

An bayyana wannan cutar ne biyo bayan nazarin halittun ɗan adam, daga babban majiyyaci da kuma a cikin yara 3. Lalacewa a cikin filaye na tsoka an yi alama ba tare da kasancewar necrosis ba. Gwaje-gwajen waɗannan raunuka (magungunan microprobes, microanalyses na radiographic, atom absorption spectrometry) ya sa ya yiwu a fahimci cewa wannan lalacewa ya ƙunshi gishiri na aluminum. Ana amfani da waɗannan abubuwa sosai a cikin adadi mai yawa na allurar rigakafin da ake gudanarwa ta cikin tsoka. An kuma nuna cewa babu wani dalili da ke haddasa cutar. Lallai, mutane masu lafiya (ba marasa lafiya, samun ingantaccen salon rayuwa, da sauransu) na iya cutar da cutar bayan allurar. (1)

Da farko dai ba a san ainihin asalin cutar ba. An tayar da zato game da muhalli, kamuwa da cuta da sauran sanadi. Ayyukan kimiyya da aka gudanar tsakanin 1998 da 2001 sun ƙaddara cewa ainihin dalilin cutar shine shan aluminum hydroxide da ke cikin alluran rigakafi. Gwaje-gwajen hoto na ƙananan ƙananan abubuwa na abubuwan ciki: macrophages sun nuna ci gaba da kasancewar abubuwan da aka haifar da waɗannan gishirin aluminum. Ana amfani da waɗannan mahadi azaman adjuvants a cikin maganin rigakafi. Macrophage myofasciitis yana samuwa ne kawai a cikin deltoid a cikin manya da kuma a cikin quadriceps a cikin yara.

Manyan alamomin da ke tattare da cutar sune kamar haka:

- ciwo mai tsanani a cikin tsokoki: ci gaban wanda yake da jinkirin (a cikin 'yan watanni). Wadannan alamun suna shafar tsakanin kashi 55 zuwa 96% na marasa lafiya da cutar ta shafa. An nuna cewa waɗannan bayyanar cututtuka gabaɗaya suna tasowa daga nesa daga ƙananan haƙarƙari kuma a hankali suna yaduwa cikin jiki duka. Ga marasa lafiya marasa lafiya, wannan ciwon tsoka yana haifar da rikitarwa na aiki. Bugu da ƙari, ana gano ciwo a cikin kashin baya akai-akai. Ana jin waɗannan raɗaɗin sau da yawa da zarar mutum ya farka kuma ana ƙarfafa su yayin motsa jiki da ayyukan yau da kullun;

- gajiya na yau da kullun, wanda ke damuwa tsakanin 36 da 100% na marasa lafiya. Wannan tsananin gajiya yakan haifar da raguwar ayyukan yau da kullum na mutum, na tunani da na zahiri;

- rashin daidaituwa na hankali, sakamakon da aka yi watsi da shi a cikin cutar. Wadannan bayyanar cututtuka suna haifar da damuwa, raguwar fahimi da aikin tunani, rashin kulawa, da dai sauransu.

Hakanan ana iya haɗawa da sauran alamun alamun cutar tare da cutar. Waɗannan sun haɗa da bayyanar cututtuka na tabin hankali, musamman rashin lafiyar yanayi.

Dyspnea (wahalar numfashi) da ciwon kai kuma an ba da rahotonsu a wasu marasa lafiya.

Asalin cutar shine kasancewar aluminum hydroxides a cikin alluran allurar da aka yi wa marasa lafiya ta hanyar intramuscularly.

Macrophage myofasciitis yana shafar maza da mata, manya da yara, ba tare da takamaiman yanayin da ake ciki ba, biyo bayan allurar rigakafi. Manya yawanci suna shafar bayan allurar rigakafi a cikin deltoid, yayin da yara ke shafar bayan allura a cikin quadriceps.

Alurar rigakafin da kasancewar gishirin aluminium ya fi shafa a matsayin adjuvant sune:

1. rigakafin cutar hanta: 84%;

2. maganin tetanus: 58%;

3. rigakafin cutar hanta A: 19%.

Bugu da ƙari, an nuna cewa kasancewar salts na aluminum a cikin jiki yana dagewa. Ko kuma cewa sanin biopsy na ƙwayar tsoka zai iya shaida kasancewar waɗannan mahadi waɗanda asalinsu alurar riga kafi ne tun shekaru da yawa. (3)

Har ila yau, yana da alama cewa akwai tsinkaye a cikin wasu mutane, ba su ƙyale su su kawar da salts na aluminum da aka samo a cikin maganin alurar riga kafi ba kuma a cikin wannan ma'anar, suna ganin sun taru a cikin ƙwayar tsoka.

Abubuwan haɗari na mutum don ci gaban cutar ba a nuna su a fili ba.

An nuna hanyar haɗi tsakanin alamun tsarin tsarin da ci gaban cututtuka a cikin ƙananan ƙananan lokuta na macrophage myofasciitis.

Bugu da kari, an yi zargin cewa kwayoyin halittarsu sun kamu da cutar, musamman a lokuta da dama da suka kamu da cutar a cikin 'yan'uwa daya. Wasu bincike na kimiyya sun nuna cewa wani nau'in gado na gado na iya yin tasiri a kan dagewar gishirin aluminum a cikin tsokar tsoka. Cutar sankara tana da haɓakar CCL2 / MCP-1 mai yawo, cytokine wanda ke da hannu cikin shigar da nanoparticles cikin kwakwalwa. Canje-canjen kwayoyin halitta a cikin kwayoyin halittar da ke ɓoye wannan kwayar halitta na iya zama ƙarin haɗarin haɓaka cutar.

Ana yin gwajin cutar bisa ga alamun asibiti daban-daban fiye ko žasa. Lallai, na farko yana da alaƙa da kasancewar salts aluminum, daga allurar rigakafi, a cikin ƙwayar tsoka.

Bugu da ƙari, kasancewar myalgia (ciwon tsoka) a cikin deltoid da ke hade da gano aluminum hydroxides a cikin wannan nama, da kuma shaidar ci gaba da ilimin cututtuka a cikin manya.

Ƙayyadewar bayyanar cututtuka (cututtukan tsoka na yau da kullum, gajiya mai tsanani da rashin fahimta) kuma ya sa ya yiwu a kafa ko a'a gano cutar.

Kyakkyawan ganewar asali na cutar ya haɗa da gano raunuka a cikin macrophages deltoid a cikin manya da kuma a cikin quadriceps a cikin yara.

A cikin 1/3 na lokuta, karuwa a matakin plasma creatine kinase shine halayyar cututtukan cututtuka. Duk da haka, wannan babban matakin cytokine na rashin daidaituwa yana iya haɗawa da wasu cututtuka masu kumburi ko tsarin rigakafi. A wannan ma'anar, dole ne a yi ƙarin gwaje-gwaje don kawar da duk wani zato na wani dalili.

Binciken electrodiagnosis, MRI (Magnetic Resonance Imaging) na tsokoki gabaɗaya yana ba da damar amincewa ko a'a ra'ayoyin farko.