Rodents sune manyan abubuwan da ke haifar da leptospirosis, amma wasu dabbobi kuma suna iya yada wannan cuta: wasu dabbobi masu cin nama ( Foxes, Mongooses, da dai sauransu), dabbobin gona ( saniya, alade, dawakai, tumaki, awaki) ko kamfani (karnuka) da ma ma. jemagu. Duk waɗannan dabbobin suna ɗaukar ƙwayoyin cuta a cikin kodarsu, galibi ba tare da rashin lafiya ba. An ce masu dauke da lafiya ne. A kodayaushe dan Adam na kamuwa da cutar ta hanyar saduwa da fitsarin wadannan dabbobin da suka kamu da cutar, ko dai a cikin ruwa ko a cikin kasa. Kwayoyin cutar kan shiga jiki ta fata ne lokacin da aka samu karce ko yanke, ko ta hanci, baki, idanu. Hakanan zaka iya kamuwa da cutar ta hanyar shan ruwa ko abinci wanda kwayoyin cutar ke ciki. Wani lokaci kuma hulɗar kai tsaye tare da dabbobin da ke iya haifar da cutar.