Shaidar canji a cikin fararen abin da ke kewaye da neurons, ci gaban leukoencephalopathy mai ci gaba da cuta cuta ce ta jijiyoyin jiki wanda a lokaci guda ke shafar yankuna da yawa na kwakwalwa kuma yana ci gaba a hankali. Dalilinsa yana da yawa. 

Neurons (ƙwayoyin jijiya a cikin kwakwalwa) ana ƙara su ta hanyar jijiyoyin jijiyoyin jiki, waɗanda ake kira axons, waɗanda za su haɗu da wasu a cikin kwakwalwa ta hanyar synapses (ƙarshen axon). Waɗannan zaruruwa na jijiya suna kewaye da ɓoɓi (myelin) wanda ke ware su daga junansu kuma yana cikin farin abin kwakwalwa.

Ci gaba mai yawa na leukoencephalopathy (PML) yana ba da shaida ga canji a wurare da yawa na kwakwalwar wannan kumburin wanda ke kewaye da axon, yana haifar da gajerun da'irori tsakanin su. Waɗannan gajerun da'irar sune asalin asalin tabarbarewa na kwakwalwa dangane da tattara tsokoki, ayyukan kwakwalwa (tunani ko sani) da na jijiyoyin jijiyoyin jijiya. Saboda haka faruwar inna, hargitsi da tunani.

Wannan cututtukan cututtukan cututtukan cututtukan ƙwayoyin cuta galibi suna ci gaba, suna haɓakawa a cikin ɓarna ko a hankali kuma a lokaci guda suna shafar wurare da yawa na kwakwalwa (multifocal). Dalilinsa yana da yawa kuma alamunsa sun dogara ne akan wuraren da abin ya shafa.

Abubuwan da ke haifar da ci gaban leukoencephalopathy mai yawa (PML) suna da yawa kuma sun bambanta a yanayi:

Gadon gado ko kwayoyin halitta

Wani lokacin farawa da wuri kamar yadda a cikin wasu cututtukan cuta ko cututtuka kamar cutar Cadasil da ke da alaƙa da maye gurbi, Ciwon Ataxia na Yara a asalin ramuka a cikin farin abin kwakwalwa ta hanyar lalata myelin, sclerosis da yawa (MS) wanda ke faruwa akan tushen gado kuma wani lokacin yana haifar da ramuka (nau'in cavitary na MS), ko cututtukan degenerative na kwakwalwa kamar cutar X mai rauni ko cutar mitochondrial.

Tushen jijiyoyin jini

Ciwon jijiyoyin jiki ne wanda ke haifar da lalacewar ƙananan tasoshin kwakwalwa (microangiopathy), mai alaƙa da shekaru, tsoho da rashin hawan jini ko ciwon sukari.

Na asali mai guba 

Ta hanyar shan wasu magunguna kamar su methotrexate da ake amfani da su wajen maganin wasu cututtukan daji ko cututtukan autoimmune (amosanin gabbai ko RA, da sauransu), guba na nitric oxide (dumama tare da gurɓataccen iskar gas) ko shakar tabar heroin (amfani da jaraba). Magungunan radadi kuma na iya canza fararen abu a kwakwalwa.

Na asalin degenerative

Yana da alaƙa da hanyoyin kumburi da ke shafar tsarin juyayi kamar MS, leucoaraiosis, ko cutar Alzheimer, wani lokacin asalin gado amma ba koyaushe ba, tare da cutar ta ƙarshe na tarin adibas wanda zai rushe watsawar neuronal (adibas amyloid da neurofibrillary degeneration hade da kasancewar sunadarai a cikin kwakwalwa, peptide beta-amyloid da furotin tau).

Asali mai cutarwa

Ba kasafai ake kamuwa da cututtukan hoto kamar papillomavirus (JC virus) ko AIDS (2 zuwa 4% na HIV + mutane).

Alamomin ci gaban leukoencephalopathy mai yawa (PML) sun bambanta dangane da wuraren da abin ya shafa da sanadin wannan tsarin gurɓatacciyar ƙwayar cuta a cikin kwakwalwa:

• jin rauni, wahalar magana ko tunani a farkon cutar;
• rawar jiki da gangan (ciwon sikila) da tashin hankali a cikin raunin X mai rauni ko cutar mitochondrial, rikice -rikice na son rai, alamun bayyana farkon waɗannan cututtukan gado ko ƙwayoyin cuta da ci gaba a hankali kuma babu makawa…;
• rikicewar tabin hankali yayin lalacewar asalin jijiyoyin jini, galibi yana faruwa daga baya a cikin tsofaffi tare da rikicewar yanayi, rikicewar hankali (rikicewar yanayin temporo-spatial, rikicewar ƙwaƙwalwar ajiya), wani lokacin rudu da rikicewa;
• raunin hankali da ƙwarewar motsi a cikin lalacewar asalin guba;
• raguwar hankali a cikin lalacewar kwakwalwa kamar cutar Alzheimer tare da raunin ƙwaƙwalwar ajiya, daidaitawa, kulawa, warware matsalar, tsarawa da tsarawa, tunani;
• haɗarin haɗarin cerebrovascular (bugun jini) yana ƙaruwa a cikin ci gaba mai yawa na leukoencephalopathy;
• migraines da epileptic seizures.

Alamun asibiti sun riga sun nuna wannan cutar, amma zai zama hoton kwakwalwa irin su Magnetic Resonance Imaging (MRI) wanda zai ba da damar gano raunukan da ke nuni da farin al'amarin kwakwalwa.

Gano cutar JC ta huɗar lumbar wani lokaci ana nuna shi idan akwai shakkar ci gaban leukoencephalopathy mai yawa na asalin ƙwayoyin cuta.

An riga an riga an gano cutar kanjamau kuma idan ba haka ba, yakamata ayi bincike.

Jiyya na ci gaban leukoencephalopathy mai ɗimbin yawa shine na sanadin:

• bincika abubuwan da ke haifar da guba (kwayoyi, tabar heroin, da sauransu) da kawar da su; 
• tabbatar da ganewar cutar tabin hankali ga cutar Alzheimer, MS, leukoaraiosis, dementia na asalin jijiyoyin jini.

Raunin fararen al'amarin zai ci gaba da kasancewa baya canzawa kuma tallafin psychosocial da motsawar hankali zai rage ci gaban wannan cutar wanda wani lokacin yana tasowa sama da shekaru da yawa.