Hypogammaglobulonemia shine raguwar matakin gamma-globulins ko immunoglobulins, abubuwan da ke da muhimmiyar rawa a cikin tsarin rigakafi. Wannan rashin lafiyar halitta na iya zama saboda shan wasu magunguna ko kuma ga cututtuka daban-daban, wasu daga cikinsu suna buƙatar ganewar asali cikin sauri. 

An bayyana Hypogammaglobulinemia ta matakin gamma-globulin da ke ƙasa da 6 g / l akan furotin plasma electrophoresis (EPP). 

Gamma globulin, wanda kuma ake kira immunoglobulins, abubuwa ne da ƙwayoyin jini suka yi. Suna da muhimmiyar rawa a cikin garkuwar jiki. Hypogammaglobumonemia yana haifar da raguwa ko žasa mai tsanani a cikin kariyar rigakafi. Yana da wuya.

Jarabawar da ke ba da izinin tantance gamma-globulins, a tsakanin sauran abubuwa, shine electrophoresis na furotin na jini ko sunadaran plasma. Ana gudanar da shi idan ana zargin wasu cututtuka ko bin sakamakon da ba a saba ba yayin gwajin farko. 

An wajabta wannan jarrabawa idan akwai tuhuma game da raunin garkuwar jiki na humoral a gaban kamuwa da cuta mai maimaitawa, musamman na ENT da bronchopulmonary sphere ko tabarbarewar yanayin gaba ɗaya, idan ana zargin myeloma da yawa (alamomi: ciwon kashi, anemia, cututtuka masu yawa…). 

Hakanan za'a iya amfani da wannan gwajin bayan mummunan sakamako wanda ke nuna karuwa ko raguwa a cikin furotin na jini, furotin mai yawa, furotin mai yawa, calcium mai hawan jini, rashin daidaituwa a cikin adadin jan jini ko farin jini.

Electrophoresis na sunadaran jini shine gwajin da ke ba da damar auna gamma globulins. 

Wannan gwajin ilimin halitta na yau da kullun (samfurin jini, yawanci daga gwiwar hannu) yana ba da damar ƙididdige tsarin ƙididdiga na abubuwan gina jiki daban-daban na maganin (albumin, alpha1 da alpha2 globulins, beta1 da beta2 globulin, gamma globulin). 

Electrophoresis na sunadarai na jini gwaji ne mai sauƙi wanda ke ba da damar ganowa da shiga cikin sa ido kan cututtukan cututtukan da yawa: cututtukan kumburi, wasu cututtukan daji, cututtukan physiological ko na abinci mai gina jiki.

Yana jagorantar ƙarin gwaje-gwajen da suka wajaba (kwayoyin rigakafi da / ko ƙayyadaddun ƙididdiga na sunadaran, ƙididdigar jini, bincike na koda ko narkewar abinci).

Gano hypogammaglobulonemia na iya zama saboda shan kwayoyi (maganin corticosteroid na baki, maganin rigakafi, anti-epileptics, ciwon daji na ƙwayar cuta, da dai sauransu) ko kuma ga cututtuka daban-daban. 

Ƙarin gwaje-gwajen suna ba da damar yin ganewar asali lokacin da aka kawar da dalilin miyagun ƙwayoyi. 

Don gano cututtukan cututtukan da ke cikin gaggawa na gaggawa (sarkar haske myeloma, lymphoma, cutar sankarar myeloid na yau da kullun), ana gudanar da gwaje-gwaje guda uku: binciken ciwon daji (lymphadenopathy, hepato-splenomegaly), gano proteinuria da ƙididdigar jini.

Da zarar an kawar da waɗannan cututtukan gaggawa na gaggawa an ambaci wasu abubuwan da ke haifar da hypogammaglobulonemia: ciwon nephrotic, exudative enteropathies. Abubuwan da ke haifar da enteropathies exudative na iya zama cututtukan hanji na yau da kullum, cutar celiac da kuma ciwon daji mai narkewa ko wasu cututtuka na lymphoid irin su lymphoma ko amyloidosis na farko (LA, sarkar haske amyloidosis na immunoglobulins).

Fiye da wuya, hypogammaglobulonemia na iya haifar da ƙarancin rigakafi na ɗan adam.

Mummunan rashin abinci mai gina jiki ko ciwon Cushing shima na iya zama sanadin hypogammaglobulonemia.

Ƙarin gwaje-gwajen suna ba da damar yin ganewar asali (na'urar daukar hoto na thoraco-abdominal-pelvic, ƙididdigar jini, aikin kumburi, albuminemia, proteinuria na sa'o'i 24, ƙaddarar nauyin immunoglobulins da rigakafi na jini)

Jiyya ya dogara da dalilin. 

Ana iya kafa maganin rigakafi a cikin mutanen da ke fama da hypogammaglobulinemia: maganin rigakafi na pneumococcal da sauran alurar riga kafi, maganin rigakafi, maye gurbin a cikin polyvalent immunoglobulins.