Hormone mai motsa jiki, ko FSH, shine babban hormone na haihuwa a cikin maza da mata. Wannan shine dalilin da ya sa yayin duban haihuwa, ana duba ƙimar sa ta tsari.

A cikin mata

HSF yana faruwa a cikin kashi na farko na zagaye na ovarian, wanda aka sani da lokaci na follicular. A wannan lokaci, wanda ke farawa a ranar farko ta haila kuma ya ƙare a lokacin ovulation, hypothalamus yana ɓoye wani neurohormone, GnRH (gonadotropin sakin hormone). A sarkar dauki zai biyo baya:

• GnRH yana ƙarfafa glandar pituitary, wanda a cikin martani yana ɓoye FSH;
• a ƙarƙashin rinjayar FSH, kusan kashi ashirin na ovarian follicles za su fara girma;
• wadannan balagagge follicles za su bi da bi za su ɓoye estrogen, alhakin thickening na mahaifa rufin domin shirya mahaifa ya sami yiwu hadi kwai;
• a cikin ƙungiyar, wani follicle guda ɗaya, wanda ake kira da rinjaye follicle, yana cimma ovulation. Za a kawar da sauran;
• lokacin da aka zaɓi babban follicle preovulatory, ƙwayar isrogen yana ƙaruwa sosai. Wannan karuwa yana haifar da karuwa a cikin LH (luteinizing hormone) wanda zai haifar da ovulation: balagagge follicle ruptures kuma ya saki oocyte.

A tsakiyar wannan aikin sarkar, FSH shine mabuɗin hormone don haihuwa.

A cikin mutane

FSH yana shiga cikin spermatogenesis da ɓoyewar testosterone. Yana kara kuzarin sel Sertoli wadanda ke samar da maniyyi a cikin tes.

A cikin mata, Za a iya ba da shawarar adadin FSH a yanayi daban-daban:

• a cikin yanayin amenorrhea na farko da / ko marigayi balaga: ana gudanar da nau'i biyu na FSH da LH don bambanta tsakanin farko (asalin ovarian) ko na biyu (babban asali: hypothalamus ko pituitary) hypogonadism;
• idan akwai amenorrhea na biyu;
• A cikin yanayin matsalar haihuwa, ana yin kima na hormonal tare da nau'in hormones na jima'i daban-daban: follicle stimulating hormone (FSH), estradiol, luteinizing hormone (LH), hormone antimuleric (AMH) da kuma a wasu lokuta prolactin, TSH (thyroid). , testosterone. Gwajin FSH yana taimakawa tantance ajiyar kwai da ingancin kwai. Yana ba da damar sanin ko rashin lafiyar ovulation ko amenorrhea ya kasance saboda ko dai don tsufa na ovarian ko kuma shiga cikin glandar pituitary.
• a menopause, ƙaddarar FSH ba a sake ba da shawarar don tabbatar da farkon farkon menopause da menopause (HAS, 2005) (1).

A cikin mutane

Za a iya yin gwajin FSH a matsayin wani ɓangare na ƙimar haihuwa, ta fuskar rashin daidaituwa na spermogram (azoospermia ko oligospermia mai tsanani), don gano hypogonadism.

Ana ɗaukar ma'aunin Hormonal daga gwajin jini, ba a kan komai a ciki ba.

• a cikin mata, ƙaddarar FSH, LH da estradiol ana aiwatar da su a ranar 2nd, 3rd ko 4th na sake zagayowar a cikin dakin gwaje-gwaje.
• a cikin mutane, ana iya yin adadin FSH a kowane lokaci.

A cikin mata:

• karuwa mai girma a cikin FSH da LH yana nuna gazawar ovarian na farko;
• raguwa mai mahimmanci a cikin LH da FSH mafi sau da yawa yana nuna lalacewa ga glandar pituitary, na farko ko na biyu (tumor, pituitary necrosis, hypophysectomy, da dai sauransu);
• idan FSH yana da girma da / ko ƙananan estradiol, ana zargin raguwar ajiyar ovarian ("farkon menopause").

A cikin mutane:

• babban matakin FSH yana nuna lalacewa na testicular ko seminiferous tubular;
• idan yana da ƙasa, ana zargin sa hannu "high" (hypathalamus, pituitary). Za a yi MRI da ƙarin gwajin jini don neman rashin wadatar pituitary.

A cikin mata:

• a cikin yanayin gazawar ovarian ko shigar da glandan pituitary, za a ba da maganin motsa jiki na ovarian. Manufarsa ita ce samar da oocytes balagagge ɗaya ko biyu. Akwai ka'idoji daban-daban, ta hanyar baka ko allura;
• a yayin da ba a kai ga menopause ba, ana iya ba da gudummawar oocyte.

A cikin mutane:

• a cikin yanayin hypogonatotropic hypogonadism (canzawa na hypotalamic-pituitary axis) tare da azoospermia mai tsanani ko oligospermia, magani don mayar da spermatogenesis za a ba da izini. Ana iya amfani da nau'ikan kwayoyin halitta guda biyu: gonadotropins tare da ayyukan FSH da gonadotropins tare da ayyukan LH. Ka'idojin, waɗanda suka bambanta bisa ga majiyyaci, suna ɗaukar watanni 3 zuwa 4, ko ma ya fi tsayi a wasu yanayi.
• a cikin yanayin canjin maniyyi mai tsanani da wasu azoospermia (wanda zai yiwu a cire maniyyi daga epididymis ko testis ta hanyar tiyata), za a iya ba da IVF tare da ICSI. Wannan dabarar AMP ta ƙunshi allurar maniyyi kai tsaye a cikin cytoplasm na balagagge oocyte;
• Za a iya ba da gudummawar maniyyi ga ma'aurata idan ba a iya dawo da spermatogenesis ba.