Kalmar "collagenosis" ƙungiya ɗaya tare da tarin cututtukan autoimmune wanda ke haifar da kumburi da lalacewar rigakafi ga nama mai haɗawa, haɓaka tsarin garkuwar jiki, fifikon mata, haɗin gwiwa tare da ƙwayoyin rigakafi na antinuclear da yaduwar raunuka. Sashin haɗin gwiwa yana nan a cikin jiki, duk gabobin suna da alaƙa da za a iya shafar su ta hanyar da ba ta da alaƙa, saboda haka babban bambancin alamun da ke iya haifar da collagenosis. Makasudin gudanarwar su shine sarrafa ayyukan cuta da rage shi zuwa mafi ƙasƙanci.

Collagenoses, wanda kuma ake kira connectivitis ko cututtukan tsarin, sun haɗu tare da tarin cututtukan cututtukan kumburi na autoimmune na yau da kullun, wanda ke haifar da samuwar haɓakar collagen a cikin kyallen takarda mai wadata a cikin matrix intercellular, watau kayan haɗin gwiwa.

Collagen shine furotin mafi yawa a jikin mu. Yana ba da damar gabobinmu da jikinmu su kasance da kwanciyar hankali ba tare da sun yi tsauri ba, yayin da suke da sassauƙa. An ɓoye shi ta ƙwayoyin sel masu haɗin gwiwa, collagen yana hulɗa tare da adadi mai yawa na sauran ƙwayoyin don ƙirƙirar fibers da samar da ƙwayar fibrous tare da kayan tallafi da shimfidawa.

Mafi mahimmanci a cikin mata, collagenases suna da ikon isa ga dukkan gabobin (tsarin narkewa, tsokoki, haɗin gwiwa, zuciya, tsarin juyayi). Wannan shine dalilin da ya sa bayyanar ta ke da yawa kamar adadin gabobin da abin ya shafa. Ingancin rayuwa wani lokacin yana da tasiri sosai. Sakamakon wadannan cututtuka ya dogara ne akan lalacewar muhimman gabobi.

Mafi sanannun collagenosis shine tsarin lupus erythematosus (SLE). Collagenosis kuma ya haɗa da cututtuka masu zuwa:

• rheumatoid amosanin gabbai;
• oculourethro-synovial ciwo (OUS);
• spondyloarthropathies (musamman ankylosing spondylitis);
• Cutar Horton;
• Granulomatose na Wegener;
• rhizomelic pseudo-polyarthritis;
• scleroderma;
• gaurayawar tsarin cuta ko ciwo na Sharp;
• la microangiopathie thrombotique;
• periarteritis nodosa;
• ciwon Gougerot-Sjögren;
• dermatomyositis;
• dermatopolymyositis;
• Cutar Behçet;
• sarcoïdose;
• histiocytosis;
• Har yanzu maladie ne;
• rashin lafiya na lokaci -lokaci;
• cututtuka masu yawa da wasu cututtuka na rayuwa;
• ciwon hanta na kullum;
• cututtuka na nama na roba;
• cututtukan da aka haifa ko waɗanda aka samu na sinadarin magani;
• scleroderma;
• Churg-Strauss ciwo;
• tsarin vasculitis, da dai sauransu.

Har yanzu ba a san su ba. Wataƙila akwai ɓarna na tsarin garkuwar jiki, kamar yadda aka tabbatar a cikin jinin marasa lafiya, kasancewar ƙwayoyin ƙwayoyin cuta, waɗanda ake kira autoantibodies ko antinuclear antibodies, waɗanda aka umarce su akan abubuwan da ke cikin sel jikin. Ana samun wasu antigens na tsarin daidaita tarihin (HLA) cikin sauƙi yayin wasu cututtuka, ko a cikin wasu iyalai da aka fi shafar su, wanda ke ba da shawarar rawar rawar da ke haifar da kwayoyin halitta.

Sashin haɗin da ke cikin jiki gaba ɗaya, ana iya shafar dukkan gabobin ta hanyar da ke da alaƙa, saboda haka iri -iri alamun da ke iya haifar da hare -hare:

• haɗin gwiwa;
• fata;
• zuciya;
• na huhu;
• hanta;
• na koda;
• tsakiya ko jijiya na gefe;
• jijiyoyin bugun gini;
• narkewa.

Juyin halittar collagenosis akai -akai yana ɗaukar yanayin sake dawowa akai -akai ana danganta shi da ciwon kumburi kuma yana canzawa daban -daban. Alamun da ba na musamman ba suna bayyana zuwa digiri daban -daban:

• zazzabi (zazzabi mai sauƙi);
• ragewa;
• gajiya na kullum;
• rage aiki;
• wahalar tattara hankali;
• hankali ga rana da haske;
• alopecia;
• hankali ga sanyi;
• bushewar hanci / baki / farji;
• raunin fata;
• rashin nauyi;
• ciwon haɗin gwiwa;
• ciwon kumburin tsokoki (myalgia) da gidajen abinci (arthralgia).

Wasu lokuta marasa lafiya ba su da alamun cutar sai haɗin gwiwa da gajiya. Sannan muna magana ne game da haɗin gwiwar da ba a bambanta ba. Wani lokaci alamun iri daban -daban na cututtukan nama na haɗin kai suna bayyana. Wannan shi ake kira ciwon haɗin gwiwa.

Saboda yuwuwar lalacewar gabobin da yawa, yana da mahimmanci cewa fannoni daban -daban na likitanci su ba da haɗin kai. Binciken ya dogara ne akan tarihi, wato tarihin mutumin da ba shi da lafiya, da gwajin asibiti, yana neman alamun da ake yawan samu a ɗaya ko fiye daga cikin waɗannan cututtukan.

Kamar yadda ake siyan collagenases ta hanyar yawan samar da rigakafin ƙwayoyin cuta na antinuclear, gwajin waɗannan abubuwan autoantibodies a cikin jini shine muhimmin abu wajen kafa ganewar asali. Koyaya, kasancewar waɗannan autoantibodies ba koyaushe yake daidai da collagenase ba. Wani lokaci kuma ya zama dole a ɗauki samfurin nama ko biopsy. Ana ba da shawarar miƙa wa ƙwararre don tabbatar da ganewar asali da fara magani da ya dace.

Makasudin sarrafa collagenosis shine sarrafa ayyukan cuta da rage shi zuwa mafi ƙasƙanci. Ana daidaita maganin gwargwadon nau'in collagenosis da aka gano kuma bisa ga gabobin da abin ya shafa. Corticosteroids (cortisone) da analgesics galibi ana amfani dasu azaman layin farko don dakatar da sake dawowa da kwantar da hankula masu zafi. Ƙarin maganin rigakafi, ta baki ko ta allura, na iya zama dole. Gudanarwa na iya haɗawa da allurar rigakafi na immunoglobulins ko dabarun tsarkakewar plasma (plasmapheresis) a cikin yanayin asibiti. Wasu marasa lafiya, kamar waɗanda ke da lupus, na iya amfana daga maganin rigakafin cutar sankara.