The cakulan rashin lafiyan mai yiwuwa ne ko da sun kasance rare. Abun rashin lafiyan a wannan yanayin ya fito ne daga sunadaran koko. Mutumin mai rashin lafiyan wanda ya cinye shi to yana fuskantar wahalar numfashi, yana da ciwon kai, rashes, tachychardia, itching da ƙonawa a ciki.

Hakanan ana iya lura da waɗannan alamun a cikin mutanen da ke rashin lafiyan abubuwan da ke yin cakulan (goro, furotin madara, da dai sauransu..), kodayake saboda haka basu da ƙima ga koko a kowane lokaci.