Contents
Sakamakon binciken nazarin halittu, wanda ke nuna matakin cholesterol a cikin jini, ya ba da damar ƙwararren ya rubuta magungunan da suka dace. Ana ba da shawarar statins sau da yawa don hana matsalolin zuciya a cikin wannan yanayin.
Yawancin lokaci, likita mai halarta, wanda ke ba da irin waɗannan kudade, nan da nan ya gargadi marasa lafiya cewa ya kamata a dauki su ba tare da dogon hutu ba. Bugu da kari, kamar sauran kwayoyi, statins suna da illa iri-iri a jiki. Ya kamata majiyyaci ya bayyana wannan batu yayin ganawa da likitansa. Bayan haka, babban aiki tare da babban cholesterol shine rage matakinsa. Ana samun sakamakon tare da taimakon magungunan ƙwayoyi. Duk da haka, ya kamata a fara magunguna a duk lokuta? Shin za a samu tasirin da ake so da taimakonsu?
Ma'anar kasancewa cikin rukunin fibrates ko statins ƙananan cholesterol. Kuna iya haɓaka tasirin su ta hanyar ɗaukar lipoic acid da Omega-3 fatty acid a lokaci guda. Wannan labarin ya keɓe ga magungunan magunguna waɗanda ke rage cholesterol, fasalin amfani da su da illa.
Rage Cholesterol tare da Statins
Rukunin magunguna na statins sun haɗa da magunguna waɗanda babban makasudin su shine rage sakin takamaiman enzymes waɗanda ke da hannu cikin haɗin cholesterol.
A cikin bayanin waɗannan kwayoyi da allunan, an ba da kaddarorin masu zuwa:
Suna aiki a matsayin mai hanawa akan HMG-CoA reductase, don haka rage cholesterol, rage yawan samar da shi;
Suna aiki ko da a gaban magunguna na yau da kullun. Misali, homozygous familial hypercholesterolemia ba zai shafi tasirin statins ba;
Yi tasiri mai kyau akan tsokar zuciya, rage yiwuwar bugun zuciya da angina pectoris;
Bayan shan magungunan, HDL-cholesterol da apolipoproteinA suna karuwa a cikin jini;
Ba kamar sauran kwayoyi masu yawa ba, statins ba mutagenic ba ne ko ciwon daji.
Ba koyaushe kwayoyi ke da amfani ga jiki ba. Statins na iya haifar da sakamako masu zuwa:
Rashin barci, ciwon kai, tashin zuciya, zawo, myalgia;
Amnesia, rashin lafiya, hypesthesia, neuropathy, paresthesia;
Rashin jin daɗi a cikin tsokoki na baya, kafafu, myopathy, rikicewa;
amai, anorexia, cholestatic jaundice;
wani rashin lafiyan dauki, bayyana ta fata kurji da itching, urticaria, anaphylaxis, exudative erythema;
Digo a cikin jini, wanda ke ba da gudummawa ga haɓakar ciwon sukari da hypoglycemia;
Yawan kiba;
ci gaban rashin ƙarfi.
Yaushe statins suke da mahimmanci?
Bayanin yawancin statins sun ƙunshi bayanan da ke nuna kaddarorin masu amfani na kwayoyi. Rage haɗarin cututtukan zuciya, daidaita matakan cholesterol, hana bugun zuciya - duk waɗannan tasirin ana ba da su ta hanyar wannan rukunin magunguna, a cewar kamfanonin talla. Duk da haka, shin da gaske haka lamarin yake? Bayan haka, farashin irin waɗannan magungunan yana da yawa, don haka bayanin game da fa'idodin statins shine ƙoƙari na jawo hankalin masu amfani? Shin da gaske suna da kyau ga lafiya?
Duk da sakamakon binciken da ke tabbatar da rashin tasirin kwayoyi a jikin mutum, ƙwararrun masana za su iya amincewa da shawarar statins don shiga. Wannan gaskiya ne musamman ga tsofaffi marasa lafiya. A gefe guda, gwaje-gwaje sun tabbatar da cewa maganin miyagun ƙwayoyi tare da statins yana taimakawa wajen rage cholesterol. Suna kuma ba da kariya daga cututtuka masu tsanani. Amma masana da yawa suna da ra'ayi daban-daban, suna gaskanta cewa tasiri mai kyau na statins yana hade da babban haɗari. Yiwuwar tasirin sakamako yana da yawa, wanda ke da haɗari sosai ga tsofaffi marasa lafiya.
A lokaci guda, kwayoyi na wannan rukuni suna wajabta wajabta a cikin waɗannan lokuta:
Lokacin da aka yi rigakafi na biyu a cikin marasa lafiya da ciwon zuciya ko bugun jini;
Tare da cututtukan ischemic tare da barazanar tasowa matsaloli daban-daban;
Tare da ciwon zuciya ko ciwon zuciya;
Tiyatar jijiyoyin jijiyoyin jini kuma ya ƙunshi shan statins.
Ba a ba da shawarar yin amfani da statins a gaban ciwon sukari mellitus, da kuma matan da ba su kai shekarun menopause ba. Babu buƙatar shan kwayoyi idan yana yiwuwa a sami madadin magunguna don guje wa illa.
Pharmacy na Rasha suna ba da amfani da statins masu zuwa tare da ayyuka daban-daban:
Rosuvastatin: Acorta, Crestor, Mertenil, Rosuvastatin, Rosucard, Rosulip, Roxera, Tevastor
Lovastatin: Cardiostatin, Choletar, Cardiostatin
Atorvastatin: Atomax, Atorvastatin, Canon, Atoris, Liprimar, Torvacard, Tulip, Liptonorm
Fluvastatin: Leskol Forte
Simvastatin: Vasilip, Zokor, Ovencor, Simvagexal, Simvakard, Simvastatin, Simvastol, Simvor, Simgal, Simlo, Sinkard
Ana samun magunguna ta hanyoyi daban-daban, farashin su ma ya bambanta.
Yadda za a zabi statins?
Dole ne mai haƙuri ya yanke shawarar kansa ko ya ɗauki statins. A wannan yanayin, ya kamata ku fara tuntuɓar ƙwararren ƙwararren wanda, idan ya cancanta, zai rubuta takamaiman magani. Ba a ba da shawarar yin kowane mataki ba tare da taimakon likita ba. Idan gwajin jini na biochemical ya nuna kasancewar duk wani rashin daidaituwa, kuna buƙatar ziyarci likitan ilimin hanyoyin kwantar da hankali da endocrinologist. Lalle ne, lokacin zabar statins, likita ya mayar da hankali kan jinsi, shekaru har ma da nauyin mai haƙuri, yana la'akari da ko yana da mummunan halaye da cututtuka na kullum.
A lokacin jiyya, wajibi ne a bi ka'idodin da ƙwararren ya kafa, yin gwaje-gwaje akai-akai. Idan ba a samu wani magani da likita ya ba da shawarar shigo da shi ba saboda tsadar tsadar kayayyaki, wanda ya saba wa yawancin statins, koyaushe kuna iya samun analog ɗin gida mai araha. Ko da yake wannan na iya rinjayar tasirin kayan aiki.
Yana da mahimmanci a tuna cewa yana da haɗari don ɗaukar ƙananan allurai na rosuvastatin a cikin cututtukan hanta na yau da kullun, wanda za'a iya maye gurbinsa da pravastatin. Ba za ku iya haɗa kwayoyi tare da barasa ko maganin rigakafi ba. Babban fa'idar pravastatin shima shine ƙarancin guba, wanda shine dalilin da yasa aka nuna shi ga marasa lafiya da ciwon tsoka. Yiwuwar hada statins da nicotinic acid shima ya kasance batun cece-kuce. Akwai ra'ayi cewa wannan zai iya haifar da mummunar cututtuka na kullum.
Me yasa statins ke da haɗari?
A cikin Rasha, an wajabta magunguna sosai bayan likitocin Amurka. Ciwon ischemic, hauhawar jini na jini - duk waɗannan cututtuka an bi da su tare da statins. A wannan yanayin, an yi amfani da manyan allurai. Duk da haka, a Amurka, ba da daɗewa ba an gudanar da wani bincike wanda ya tabbatar da dangantaka tsakanin ci gaban cututtuka da yawa da kuma amfani da statins. A cikin 2013, Jaridar Likita ta Burtaniya ta buga bayanai game da mummunan tasirin su akan lafiyar marasa lafiya. Amma babu wani karatu mai zaman kanta a Rasha, kuma kwararru sun ci gaba da yin amfani da kwayoyi na wannan rukuni.
A Kanada, an gano cewa tsofaffi marasa lafiya da ke shan su sau da yawa sun fuskanci saurin lalacewa a hangen nesa da kuma ci gaban cataracts. Haɗarin yana ƙaruwa sosai a gaban ciwon sukari.
Wasu hujjoji suna sanya shakku kan fa'idodin statins:
Magunguna na iya shafar cholesterol don ya zama ƙasa da al'ada, wanda ya fi haɗari fiye da wuce gona da iri. Yana iya haifar da mugayen ciwace-ciwace, cututtukan hanta, anemia, bugun jini, kashe kansa da baƙin ciki.
Statins suna tsoma baki tare da aikin dawo da cholesterol. Godiya ga cholesterol, an kawar da lalacewa a cikin jiki. Wannan shi ne saboda gaskiyar cewa yana daya daga cikin muhimman abubuwan da ke cikin abubuwan da ke tattare da tabo. Har ila yau, mummunan cholesterol yana da mahimmanci ga ci gaban ƙwayar tsoka da dukan jiki. Rashinsa yana haifar da ciwon tsoka da dystrophy.
Rashin Magnesium, ba wuce haddi cholesterol ba, yana haifar da bugun jini da bugun zuciya. Wannan hasashe yana jefa shakku kan buƙatar amfani da statins.
Tare da raguwar matakan cholesterol, haɗin sauran abubuwa masu mahimmanci a cikin jiki kuma yana raguwa. Wannan ya shafi irin wannan fili kamar melovanate. Yana da hannu a yawancin ayyukan nazarin halittu, gami da samuwar cholesterol.
Ayyukan statins suna haifar da ciwon sukari mellitus, wanda hakan ke haifar da mummunan tasiri ga samar da cholesterol kuma yana ba da gudummawa ga faruwar wasu cututtuka. Wannan dalili, a cewar masu bincike a Jamus, yana haifar da angina pectoris da arrhythmia, bugun jini. Wannan yana faruwa ne saboda raguwar yawan furotin da ke da alhakin matakan sukari na jini. Bisa ga sakamakon bincike, matan da ke cikin shekarun haila suna cikin haɗari.
Akwai matsaloli a cikin kwakwalwa saboda shan kwayoyi. Da farko dai, statins suna shafar cholesterol metabolism, wanda ke shafar aikin hanta. A lokaci guda, kwayoyi suna da tasiri mai kyau akan tasoshin jini. Duk da haka, duk wani tasiri na sinadarai yana da lahani ga jiki. A sakamakon haka, canje-canjen da ba za a iya canzawa ba suna faruwa a cikin tsarin ilimin lissafi, ciki har da aikin tunani na iya damuwa.
Sau da yawa ana gano illolin statins da latti.
Wasu masana kimiyya, suna la'akari da high cholesterol a matsayin tabbatar da kasancewar cututtuka masu tsanani, suna nuna damuwa da sauran kumburi a matsayin abubuwan da ke haifar da cututtukan zuciya. Yawancin ƙasashe sun daɗe suna haɓaka salon rayuwa mai kyau don hana matsaloli a cikin aikin zuciya. Godiya ga wannan, adadin marasa lafiya da irin waɗannan cututtukan ya ragu, wanda ya tabbatar da cewa cholesterol za a iya daidaita shi ta hanyar barin halaye mara kyau da zaɓin wasanni da abinci mai kyau. Don haka, salon rayuwa mai kyau yana ba ku damar guje wa shan magunguna daban-daban waɗanda ke da babban adadin sakamako masu illa, kuma ku guje wa ci gaban cututtukan cututtuka masu haɗari.
Wani mummunan abu daga shan statins
A cewar wani bincike na mutane 3070 masu shekaru 60 da haihuwa, amfani da statin yana haifar da ciwon tsoka a cikin 30% na mutane, wanda ke iyakance ayyukansu na jiki. A sakamakon karuwar ciwo a cikin tsokoki, marasa lafiya sun ƙi yin wasanni, tafiya ƙasa. Duk waɗannan abubuwan suna haifar da hauhawar nauyi kuma suna ƙara haɗarin cututtukan zuciya.
Fibrates yana Taimakawa Ƙananan Cholesterol
Abubuwan da ake samu na Fibric acid da aka sani da fibrates ana amfani da su azaman madadin statins. Suna aiki kai tsaye akan hanta, rage fitar da cholesterol. Fibrates kuma yana shafar adadin lipids, yana rage samuwar adibas na extravascular. Bayan shan waɗannan magungunan, an daidaita matakin cholesterol mai kyau da mara kyau.
Tare da sakamako masu kyau, fibrates kuma suna da mummunar tasiri, wanda aka bayyana a cikin nau'i na:
Hepatitis, pancreatitis, zawo, tashin zuciya, amai, zafi a cikin tsarin narkewa;
venous thromboembolism, huhu embolism;
raunin tsoka da spasms, yada myalgia;
ciwon kai, rashin aikin jima'i;
Hasken hankali da halayen rashin lafiyan.
Sau da yawa, ana amfani da magani mai mahimmanci, wanda ya haɗa da haɗin fibrates da statins. Don haka, yana yiwuwa a rage yawan adadin na ƙarshe.
Fibrates suna wakilta da tsararraki uku:
Clofibrate - fibrates da ba a yi amfani da su ba na ƙarni na 1st, yanzu ba a yi amfani da su ba, tun lokacin da aka tabbatar da cewa yana taimakawa wajen bayyanar cututtuka;
Gemfibrozil, bezafibrate - tsarin yana da kama da clorifbrate, amma yana da ƙarancin guba. Har ila yau, ana la'akari da shi mara amfani, yanzu da wuya a yi amfani da shi;
Fenofibrate, Ciprofibrate - nasa ne na ƙarni na 3 na fibrates, yanzu shine mafi mashahuri. Baya ga rage cholesterol, yana rage matakin uric acid, kuma yana rage yiwuwar rikitarwa na ciwon sukari. Ana sayar da su a ƙarƙashin sunayen kasuwancin Traykor (Faransa), Lipantil 200 M (Faransa), Fenofibrate Canon (Rasha), Exlip (Turkiyya).
Rage yawan shan cholesterol na hanji
Yawancin abubuwan da ake buƙata na yau da kullun don cholesterol suna cika ta jiki, sauran ana cika su ta hanyar abinci.
Daidaita matakan cholesterol tare da shirye-shirye na halitta
Yawancin likitoci sun ba da shawarar maimakon statins da fibrates don rage matakan cholesterol tare da hanyoyi masu zuwa:
Omega-3 mai mai. Ana samun su da yawa a cikin man kifi da man flaxseed, kuma suna aiki azaman rigakafin bugun jini, cututtukan jijiya, da amosanin gabbai. A lokaci guda, ba za a keta adadin man kifi ba, tun da wuce haddi na iya haifar da pancreatitis.
Kabewa. Wannan magani na halitta shine man kabewa. An yi amfani dashi don hana atherosclerosis na tasoshin cerebral, hepatitis, cholecystitis, yana da anti-mai kumburi, hepatoprotective, choleretic da antioxidant effects.
Lipoic acid. Yana hana atherosclerosis na jijiyoyin jini, tasiri akan matakin glycogen a cikin hanta. Tare da taimakon lipoic acid, neuronal trophism za a iya inganta.
Vitamin far. Mafi kyawun tushen abubuwan da ake buƙata don jiki shine samfuran halitta masu wadatar nicotinic da folic acid, bitamin B3, B6, B12.
abin da ake ci kari Daga cikin waɗannan, yana da kyau a yi amfani da SitoPren - cire ƙafar fir. Ya ƙunshi beta-sitosterol, abun da ke ciki kuma ya ƙunshi polyprenols, da amfani a atherosclerosis, ciwon sukari.