Bullous pemphigoid cuta ce ta fata (dermatosis).

Na ƙarshen yana halin haɓaka manyan kumburi a kan faranti na erythematous (jajayen alamomi a fata). Bayyanar waɗannan kumfa yana haifar da raunuka kuma galibi shine sanadin ƙaiƙayi. (1)

Yana da cututtukan autoimmune, sakamakon rushewar tsarin garkuwar jiki a cikin mutumin da abin ya shafa. Wannan ƙa'idar tsarin garkuwar jiki ta ƙunshi samar da takamaiman ƙwayoyin rigakafi akan jikinsa.

Wannan cuta ba ta da wuya amma tana iya zama mai tsanani. Yana buƙatar magani na dogon lokaci. (1)

Kodayake cuta ce da ba a saba gani ba, ita ce kuma mafi yawan cututtukan cututtukan fata. (2)

Yawanta shine 1 /40 (adadin lokuta da mazauna) kuma galibi yana shafar tsofaffi (a matsakaita kusan shekaru 000, tare da ƙara haɗarin mata).

Haka kuma akwai tsarin haihuwa wanda ke shafar yaron a shekarar farko ta rayuwarsa. (3)

Bullous pemphigoid shine dermatosis na asalin autoimmune. Batun da ke fama da wannan cuta saboda haka yana haifar da ƙwayoyin rigakafi akan jikin sa (autoantibodies). Waɗannan suna kai hari ga nau'ikan sunadarai guda biyu: AgPB230 da AgPB180 wanda ke tsakanin yadudduka biyu na fata na farko (tsakanin fata da fatar jiki). Ta hanyar haifar da rarrabuwar kawuna tsakanin waɗannan ɓangarorin fata guda biyu, waɗannan ƙwayoyin rigakafi suna haifar da samuwar ɓoyayyun halayen cutar. (1)

Alamomin atypical na pemphigoid mai ban tsoro shine bayyanar manyan kumfa (tsakanin 3 zuwa 4 mm) da launi mai haske. Waɗannan kumfa galibi suna faruwa ne a inda fata take da ja (erythematous), amma kuma tana iya fitowa akan fata mai lafiya.

Cututtukan epidermal galibi ana sanya su a cikin akwati da gabobin jiki. An fi kiyaye fuska sau da yawa. (1)

Ciwon fatar jiki (ƙaiƙayi), wani lokacin farkon lokacin da kumfa ya bayyana, shima yana da mahimmanci ga wannan cutar.

An nuna nau'o'in cutar da dama: (1)

- siffar gama -gari, alamominsa sune bayyanar manyan kumburin fari da ƙaiƙayi. Wannan fom ɗin ya fi yawa.

- siffar vesicular, wacce aka ayyana ta bayyanar ƙanƙara ƙanƙara a cikin hannayen tare da matsanancin ƙaiƙayi. Wannan fom din ba kasafai ake samunsa ba.

- fatar urticarial: kamar yadda sunansa ya nuna, yana haifar da facin amya kuma yana haifar da matsanancin ƙaiƙayi.

-siffar prurigo, wanda itching ɗin ta yaɗu amma mai tsanani. Wannan nau'in cutar kuma na iya haifar da rashin bacci a cikin abin da abin ya shafa. Bugu da ƙari, ba kumfa ba ne waɗanda ake iya ganewa a cikin nau'in prurigo amma ɓawon burodi.

Wasu marasa lafiya na iya ba su da wata alama. Wasu kuma suna samun ɗan jajaye, ƙaiƙayi, ko haushi. A ƙarshe, al'amuran da suka fi faruwa suna haifar da ja da itching mai tsanani.

Ƙulle -ƙulle na iya fashewa da haifar da ulcers ko buɗaɗɗen raunuka. (4)

Bullous pemphigoid shine autoimmune dermatosis.

Wannan asalin cutar yana haifar da samar da garkuwar jiki (sunadarai na garkuwar jiki) ta jiki akan sel nasa. Wannan samar da autoantibodies yana haifar da lalata kyallen takarda da / ko gabobi da halayen kumburi.

Har yanzu ba a san ainihin bayanin wannan lamari ba. Koyaya, wasu dalilai zasu sami hanyar haɗin kai tsaye ko a kaikaice tare da haɓaka ƙwayoyin ƙwayoyin cuta. Waɗannan su ne muhalli, hormonal, magani ko ma abubuwan gado. (1)

Waɗannan abubuwan autoantibodies waɗanda abin da abin ya shafa ke jagoranta ana yin su akan sunadarai guda biyu: BPAG1 (ko AgPB230) da BPAG2 (ko AgPB180). Waɗannan sunadarai suna da rawar tsari a cikin haɗin tsakanin dermis (ƙananan Layer) da epidermis (babba babba). Waɗannan macromolecules waɗanda autoantibodies ke kaiwa hari, fatar jiki tana cirewa kuma tana haifar da kumfa. (2)

Bugu da ƙari, babu wani kamuwa da cuta da za a haɗa shi da wannan cutar. (1)

Bugu da ƙari, alamun cutar gaba ɗaya suna bayyana kwatsam kuma ba zato ba tsammani.

Pemphigoid mai ban tsoro ba, duk da haka: (3)

- kamuwa da cuta;

- wani alerji;

- yanayin da ya shafi salon rayuwa ko abinci.

Bullous pemphigoid cuta ce ta autoimmune, ta wannan hanyar ba cuta ce ta gado ba.

Duk da haka, kasancewar wasu kwayoyin halitta zai zama haɗarin kamuwa da cutar a cikin mutanen da ke ɗauke da waɗannan kwayoyin. Ko dai akwai wani tsinkayen halitta.

Wannan haɗarin tsinkaye shine, duk da haka, yayi ƙasa sosai. (1)

Tun da matsakaicin shekarun ci gaban cuta ya kusan 70, shekarun mutum na iya zama ƙarin haɗarin haɗari don haɓaka pemphigoid.

Bugu da kari, ba za mu manta da gaskiyar cewa wannan cutar ma an bayyana ta ta hanyar haihuwa. (3)

Bugu da kari, ana iya ganin dan kadan na cutar a cikin mata. Saboda haka jinsi na mace yana sanya shi haɗarin haɗarin haɗari. (3)

Bambanci daban -daban na cutar shine galibi gani: bayyanar bayyanannun kumfa a cikin fata.

Ana iya tabbatar da wannan ganewar ta biopsy na fata (ɗaukar samfurin daga lalacewar fata don bincike).

Ana iya amfani da immunofluorescence a cikin zanga -zangar ƙwayoyin rigakafi bayan gwajin jini. (3)

Magungunan da aka ba da izini a cikin mahallin kasancewar pemphigoid mai ƙima yana nufin iyakance ci gaban kumfa da warkar da kumfa da ke cikin fata. (3)

Mafi yawan maganin da ke da alaƙa da cutar shine tsarin corticosteroid na tsari.

Koyaya, don nau'ikan pemphigoid masu ƙyalli, maganin corticosteroid na jiki (kawai yin aiki inda ake amfani da miyagun ƙwayoyi), haɗe tare da aji I dermatocorticoids (maganin da ake amfani da shi a cikin maganin fata na gida). (2)

Magunguna don maganin rigakafi na dangin tetracycline (wani lokacin hade da shan bitamin B) na iya zama mai tasiri ga likita.

Sau da yawa ana ba da magani don dogon lokaci kuma yana da tasiri. Bugu da kari, ana iya ganin koma bayan cutar a wasu lokuta bayan dakatar da magani. (4)

Bayan ganewar kasancewar pemphigoid mai ban tsoro, ana ba da shawarar shawarar likitan fata. (3)